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Intranasal Absorption and CNS Penetration The intranasal route delivers Semax directly to the brain via olfactory and trigeminal nerve pathways, achieving CNS concentrations impossible through systemic dosing

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With the short, thin needles used for subcutaneous injection (29- or 31-gauge insulin syringes), a 90-degree angle is typically appropriate

In cases where absorption is compromised, high oral doses or very high doses (such as 1,0002,000 mcg) of vitamin B12 may be required to correct deficiency, as these can sometimes be effective alternatives to injections

doi: 10.1002/ccs3.12039