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The accumulation of lactate facilitates cancer cell regeneration

The following reflects current understanding based on phase 2 data and the established safety profiles of approved GLP-1 receptor agonists per UK Summary of Product Characteristics (SmPCs)

They do not quantify how many patients might experience stomach paralysis or how impactful it can be on a persons daily life

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Starting both agents concurrently would expose GLP-1 receptors to additive agonism during the titration phase, likely increasing nausea and vomiting without a defined clinical benefit