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Os pesquisadores relataram reduo de peso corporal proporcional dose utilizada, com efeitos adversos predominantemente gastrointestinais, de carter transitrio e dose-dependente, perfil semelhante ao observado em outros agonistas de receptores relacionados ao GLP-1

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In a Phase 2a substudy published in Nature Medicine, retatrutide at the 12mg dose reduced liver fat by an average of 82.4% from baseline at 24 weeks