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The decreased NADPH production results in insufficient reduction of oxidized glutathione disulfide (GSSG) and Prdx2, thus rendering the antioxidant system less effective ( Classes of Mutation and Spectrum of Deficiency G6PD deficiency is a heterogeneous condition with 217 mutations reported as of 2016

FOXO4-DRI is a lab-made peptide built as a mirror-image (D-retro-inverso) version of part of the FOXO4 protein

Larger peptides and those without specific transport mechanisms may have limited BBB penetration, which is why administration route matters so much for neurological applications

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