semaglutide for insulin resistance pcos in polycystic ovary syndrome across various tissues: an updated review of pathogenesis, evaluation, and treatment | Journal of Ovarian Research GLP-1s and PMOS: PCOS, Insulin

doi:10.1152/ajpgi.1990.259.4.G530 33

It has been shown that tryptophan metabolism is enhanced in COVID-19 infection, leading to a decrease in tryptophan and increased levels of kynurenine metabolites (43), which can have multiple deleterious effects on the musculoskeletal system (70)

They are the standard of care in managing type 2 diabetes, with a strong track record of reducing HbA1c levels and improving cardiovascular outcomes

The authors hoped their GLP-1 agonist Lixisenatide would reach this threshold

PMID: 27329332 van Dronkelaar C, et al

These guidelines emphasize that SGLT-2is should be used in populations with T2DM-CKD to lower the incidence of MACEs