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Zepbound is administered as a once-weekly subcutaneous injection, with doses typically starting at 2.5 mg and gradually increasing to a maintenance dose of 5 mg, 10 mg, or 15 mg based on individual response and tolerability

MacLusky NJ, Cook S, Scrocchi L, Shin J, Kim J, Vaccarino F et al (2000) Neuroendocrine function and response to stress in mice with complete disruption of glucagon-like peptide-1 receptor signaling

Inform patients that nausea, vomiting and diarrhea are most common when first starting semaglutide, but decreases over time in the majority of patients