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The B12-intrinsic factor complex travels to the terminal ileum, where it binds to specific receptors (cubilin-amnionless complex) and is absorbed through receptor-mediated endocytosis

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Moreover, a US national study of 2,806 older women (50 years) found increased plasma concentration of methylmalonic acid the metabolic indicator of vitamin B 12 deficiency to be associated with increased risk of lumbar spine osteoporosis (115)