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Mutations in KRAS or BRAF are found in approximately half of the cases of colorectal cancer (CRC) and their expression correlates with an increase in GLUT1 expression, glucose uptake and reliance on glycolysis

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Hence, gp34 1-179W65F together with the ectodomain region of an Fcnonrelated protein, ICOS-L 1-268 , were used as controls

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These two genes were duplicated during the second whole-genome duplication event (2R) to create four new somatostatin genes: SS1, SS2, SS3 , and one gene that was lost during the evolution of vertebrates