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Combining GLP-1RAs with glucagon significantly inhibits fat production by suppressing the expression of sterol regulatory element-binding protein-1c and -hydroxy -methylglutaryl-CoA reductase

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In addition, body composition changes favor a decline in lean body mass and an increase in fat distribution

Discontinuing prematurely may prevent any meaningful assessment of efficacy

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10.1016/j.kint.2016.01.009 Kidney Int