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Rapid weight loss can signal energy deficiency to the hypothalamus, potentially suppressing gonadotropin-releasing hormone (GnRH) secretion

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Disease severity and duration play crucial rolespatients with longstanding type 2 diabetes, significant beta-cell dysfunction, or severe obesity typically require longer treatment durations than those with early-stage disease or modest metabolic abnormalities

doi: 10.1002/mnfr.201900525

Long-term treatment planning is an important conversation to have with a healthcare provider before starting therapy

Bloomberg Businessweek reports on an $18.7 billion gap