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Tirzepatide's binding kinetics at GLP-1R result in lower beta-arrestin recruitment relative to cAMP generation, a biased agonism profile, which may partly explain the sustained glucose-lowering effect observed across 40 weeks in SURPASS-2 [19]

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All insulins, including Toujeo, can lead to life-threatening hypokalemia

10.1007/s00125-011-2440-x

Oxidative DNA damage is associated with inflammatory response, insulin resistance and microvascular complications in type 2 diabetes