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A 5 to 10 beat per minute increase that a 35-year-old barely notices might cause fatigue, exercise intolerance, or shortness of breath in a 65-year-old

Nutriologa Mdica

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Nature 464 , 121125 (2010)

doi: 10.1212/CON.0000000000001160 50 Rode Karan GaneshM.JadhavV.SanapG

Sanger sequencing for segregation of BBOX1 variants in Patient 2 was performed in the Rare Disease Discovery Hub project ( Serum and dried blood spot acylcarnitine profile Acylcarnitine profiles were tested in serum and dried blood spot samples at the Biochemical Genetics Laboratory at BC Childrens Hospital according to the standard clinical protocols