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Retatrutide (development code LY3437943) is a 39-amino acid synthetic peptide developed by Eli Lilly as the first triple-receptor agonist targeting GLP-1R, GIPR, and GCGR in a single molecule

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Semaglutide in particular has been popularized through celebrity endorsements and social media influencers, 16 and prescription volumes have increased rapidly in recent years

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In clinical trials, participants ate in a calorie deficit (consuming around 500 fewer calories per day) and exercised for about 150 minutes per week

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