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Biomarkers of mitochondrial dysfunction in autism spectrum disorder: a systematic review and meta-analysis

For instance, a comprehensive study published in Obesity Reviews indicated that without structured dietary and exercise interventions, individuals on GLP-1 medications experienced muscle loss comprising up to nearly half of their total weight loss (Wilding et al., 2021)

Phentermine carries its own safety profile: it is a controlled substance approved only for short-term use (12 weeks or less) and is contraindicated in patients with uncontrolled hypertension, coronary artery disease, or history of substance abuse

This exclusion is consistent with standard practice for GLP-1 receptor agonist trials, based on rodent studies showing C-cell tumours with GLP-1 receptor agonists