Preclinical studies showed preferential reduction of abdominal and visceral adipose tissue, suggesting favorable body composition changes even when total weight loss is moderate
It makes sense from like a rehab standpoint, its probably why its effective, maybe, but its also the same biological pathway that makes tumors grow, and that is a little concerning to me
Fortunately, our current lipotropics have some B-12 in them as well, further supporting energy and immune function
A second pathway, ERK1/2 signalling, governs cell survival and fibroblast activity, and appears especially relevant in tissue thats naturally poor in blood supply, tendons and ligament junctions being the clearest examples (Rodgers et al., 2025)
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Some patients tolerate gradual adjustments better than aggressive protocols