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Many of these older drugs had been grandfathered in when the new drug approval process was established in the 1960s, so they had never undergone clinical studies to secure FDA approval
317,318 Common adverse events are diarrhea, headache, abdominal pain, and flatulence
Effect of colchicine on perioperative atrial fibrillation and myocardial injury after non-cardiac surgery in patients undergoing major thoracic surgery (COP-AF)
Safety Directions: It may irritate the eyes and skin
Limitations And Risks Of IV Glutathione Despite its popularity, IV therapy has important trade-offs: Inconvenience and time - requires clinic visits, an IV line, and staff Cost - regular infusions can become expensive as a long-term strategy Needle and infection risk - any IV access carries a small risk of infection, bruising, or vein irritation Short-lived peaks - blood glutathione levels often spike and then fall relatively quickly after infusion Targeting limits - IV therapy raises systemic levels but does not specifically direct glutathione to the sinuses or brain Side effects are usually mild (flushing, lightheadedness, nausea), but rare allergic reactions or breathing changes can occur
