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Dimethyl sulfoxide (DMSO) exacerbates cisplatin-induced sensory hair cell death in zebrafish (Danio rerio)

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Mee's modern adaptation of Aeschylus' The Suppliant Women Date: March 1, 2016 Event: Theatrical Performance: "Big Love" Location: Mathers Theatre, Dickinson College Hannah Guy-Mozenter "Big Love" Charles L

There are 2 primary mechanisms: Ascorbic Acid (Ascorbate) uptake using sodium-dependent vitamin C transporter (SVCT) 1 or 2 Ascorbic Acid (Ascorbate) Recycling Ascorbic Acid (Ascorbate) transport using sodium-dependent vitamin C transporter (SVCT) 1 or 2 As shown below, SVCT 1 and SVCT 2 transport ascorbic acid or ascorbate into the cell against the concentration gradient (represented by the orange wedge in the figure below)

They developed a fusion protein of the ROS scavenger glutathione peroxidase (GPX1) (that can neutralize superoxide and peroxide) and TRF1 (to localize GPX1 to telomeres)