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Are pregnant or plan to become pregnant (it is recommended to stop semaglutide at least 2 months before planning conception)

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It targets suppressor of cytokine signaling 1 (SOCS1) to alleviate the suppression of JAK/STAT signaling [44], inhibits the transcription factor ETS1 to increase STAT3 activation, strengthens the prodifferentiation effect of cytokines such as IL-23 and IL-6 [45, 46], and suppresses the epigenetic regulator Jarid2 to directly or indirectly relieve the transcriptional repression of Th17-related genes [47]

(2009) 32 Suppl 1:S6267

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