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Clinical trials including the SUSTAIN series (semaglutide) and SURPASS trials (tirzepatide) document net cardiovascular benefit in participants with or at risk for type 2 diabetes

Tryptophan at position 9 is the principal photolabile residue and oxidises readily, with tyrosine at position 2 and histidine at position 6 secondary sites of concern

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We observed consistent and diverse individual variability in fasting response, which could be explained partly by their similarity or differences in BMI, lipid storage, and sex

This is why tirzepatide outperforms semaglutide in most clinical studies