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When assessing how APA influences the risk of adverse birth outcomes, there has been a predominant focus on how APA affects reproductive function through variables such as paternal DNA integrity, sperm quality, and hormonal changes

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The induced Tregs are predominantly the IL-10 + cytotoxic-T-lymphocyte-associated antigen-4 (CTLA4) high Helios-subset with potent immunosuppressive activity, and they can migrate to extraintestinal organs to suppress systemic inflammation

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