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However, different from the predicted binding mode of ghrelin, all the peptide moiety of ghrelin occupies the large cavity I while the octanoyl moiety attached to Ser3 of ghrelin extends into the small cavity II in the structure of ghrelin-bound GHSR (Fig

TB-500 is a synthetic peptide corresponding to a fragment (typically the 17-amino-acid active region) of that protein

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Or it resolves to in vitro work at nanomolar concentrations, which is six orders of magnitude away from a milligram dose and cannot generate one