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some participants also had type 2 diabetes

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In islet alpha cells, GLP-1(936) led to inhibition of Ca 2+ entry via voltage-gated Ca 2+ channels sensitive to -agatoxin, with consequential pertussis-toxin-sensitive depletion of the docked pool of secretory granules, effects that were prevented by the glucagon receptor antagonists REMD2.59 and L-168049

Phase II data (NEJM, 2023) showed up to 24.2% mean body weight reduction with Retatrutide at 12mg weekly over 48 weeks, compared to approximately 21% with Tirzepatide at 15mg in the SURMOUNT trials over comparable periods

For semaglutide, the dosage chart in units helps researchers fine-tune their escalation

Separating evidence from hype requires looking at the actual studies, their limitations, and what they do and do not prove