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Data from a large retrospective cohort study to be presented at the 2026 American Society of Clinical Oncology (ASCO) Breakthrough Meeting showed that GLP-1 receptor agonist (GLP-1 RA) use was significantly associated with lower colorectal cancer incidence among patients with inflammatory bowel disease (IBD), including those with comorbid type 2 diabetes (T2D)

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Second, it reshapes MAPK signaling in a way that may steer cells away from acute inflammation and toward recovery

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Recent studies have shown that a high insulin demand causes some cells to go into a high-stress, low-insulin secretion phase (59)