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Gut microbiota-derived metabolites, particularly SCFAs like butyrate and acetate, play critical roles in maintaining metabolic and immune homeostasis, with dysbiosis-linked alterations implicated in the pathophysiology of numerous neurological disorders including stroke, AD, and PD (Mirzaei et al., 2021)

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Maintaining regular meal times and avoiding prolonged periods without eating may help stabilise metabolic processes that could influence temperature regulation

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(127), others have suggested that a decrease in food intake occurs in H3R-KO mice, however, food intake was normalized to body weight, making any absolute changes difficult to assess (129)

Van Dam NT, Earleywine M