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When a substance like Ipamorelin is introduced abruptly at a higher Ipamorelin dosage , the body may react with side effects such as headaches, increased hunger, or water retention

These may occur with or without pain, and, as with other injection site reactions, usually go away on their own within a few days

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For patients with complex chronic illnesses who often already suffer from irritable bowel syndrome (IBS), mast cell activation syndrome (MCAS), or general gut sensitivity, this laxative effect is entirely counterproductive and can lead to further dehydration and electrolyte imbalance

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The FDA-reviewed prescribing information for Wegovy (semaglutide 2.4 mg) discloses that in the SELECT cardiovascular outcomes trial - which enrolled adults with established cardiovascular disease - hip and pelvis fractures were reported more often in female patients on Wegovy than in those on placebo: 1% (24 of 2,448 patients) versus 0.2% (5 of 2,424 patients)