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The -amino group of Lys 185 acts as a general base, abstracting a proton from the hydroxyl group at C-3 of 6-phosphogluconate

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26 However, previous studies showed that ERK phosphorylation is barely suppressed in several colon tumor cell lines treated with IGF-1R inhibitor, OSI-906

NADPH oxidases: redox regulation of cell homeostasis and disease