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A subset of cultured cells expressed GLP- 1 receptor, and mice with a-cell specific GLP- 1 receptor knockout have mild glucose intolerance and higher glucagon secretion in response to glucose challenges than animals of the wild type, which may indicate that GLP- 1 directly affects this cell [69]

Inflamed synovium produces prostaglandins, leukotrienes, ROS, cytokines, chemokines, and adipokines, all of which contribute to cartilage breakdown and further exacerbate inflammation (Scanzello and Goldring, 2012)

Additional CD4 + subsets such as T follicular helper (Tfh) cells enhance B cell activation and autoantibody production, with higher Tfh counts linked to more severe disease (Cai et al., 2022)

Sulfasalazine could modulate the CD44v9-xCT system and enhance cisplatin-induced cytotoxic effects in metastatic bladder cancer

5a, b, TGF expression in the IVDs from post-PELD patients was significantly higher than that in the IVDs from normal healthy IVD patients