Figure 2 MicroRNAs and A Pathway Disruptions Although amyloid deposition alone is not able to produce full AD-pathology, studies that used A PET in cognitively normal elderly individuals, mild cognitive impairment (MCI) and AD patients found significant relationships between cognitive deficits and increased brain fibrillar A (Wang F
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10.1016/j.molmed.2015.02.002 Trends Mol
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If we dont change the oil filter periodically, the cars engine will diminish its performance and give less mileage. Similarly, if the balance between free radical production and antioxidant response in cells consistently favors the former, in time cellular function could be disrupted
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