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SIRT2 deacetylates and inhibits the peroxidase activity of peroxiredoxin-1 to sensitize breast cancer cells to oxidant stress-inducing agents

Total (AUCIDeg,0 120h,SD) and peak exposure of TRESIBA were on average about 10 25% and 13 27% higher, respectively in subjects with mild to severe renal impairment except subjects with ESRD who showed similar exposure as compared to subjects with normal renal function

Iron triggers the Fenton reaction and associated ROS production, which, in turn, triggers ferroptosis-promoting lipid peroxidation [163]

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Oncotarget (2017) 8:63890900