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The chemistry concern is that disrupting the chelate releases free copper, which behaves very differently in formulation than the chelated peptide

These experimental results demonstrated that NP4 could activate macrophages, facilitate DCs maturation, increase infiltration of cytotoxic T cells, activate the mouse immune system, and inhibit tumor growth in osteosarcoma

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There should also be other clinical trials of wider ranges to ascertain the efficacy and safety of different formulations, including S-acetyl-glutathione