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Ipamorelin is a synthetic peptide classified as a growth hormone secretagogue and a selective ghrelin receptor agonist
In this model, ligation acts as (i) a mechanical trauma on the dentogingival area, thereby reducing tissue integrity and allowing for intense host-plaque interaction and (ii) a plaque-formation-promoting factor, thus increasing the number of bacteria
Learn more about hydrolyzed collagen or soluble collagen
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One is dose-related and the other is dose-independent
Research teams that assume 'endogenous molecule = safe to combine' are ignoring receptor affinity data and downstream signaling cascades that create risk independent of molecular origin
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