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Compared with placebo, weight loss achieved with all doses of cagrilintide was statistically significant, estimated difference range was 3.0 Percentage to 7.8 Percentage (P less than 0.001) [9]

La HbA1c y el peso disminuyeron significativamente: 0.39% y 4.6 kg, respectivamente

As mitochondria are the primary source of ROS, improving mitochondrial function is a key mechanism by which SIRT1 mitigates oxidative stress to alleviate MAFLD

Due to the complexity of NASH, no current treatment is approved for it (126) and most therapies remain to be traditional and focus on lifestyle intervention, which is difficult to maintain (127)

Related studies have indicated a causal relationship between IR and all clinical symptoms of PCOS, with weight loss being shown to improve the reproductive function, hyperandrogenism and metabolism of women with PCOS (155, 156)