Endogenous MOTS-c levels decline as we age
Best for: MTHFR mutations (C677T, A1298C) Supporting methylation directly Neurological symptoms (brain fog, neuropathy) Depression and mood disorders Elevated homocysteine Advantages: No conversion required immediately bioavailable Directly supports methylation cycle Crosses blood-brain barrier easily Lowers homocysteine effectively Potential downsides: Can cause overmethylation symptoms in sensitive individuals (anxiety, insomnia, irritability) May need to start with very low doses Not ideal for those with histamine issues or overmethylators Typical dosage: 500-5000mcg daily (start low) 2
Results showed the mix was highly effective in this challenging population, producing average weight loss of 20-22% over 68 weeks compared to 12-14% with semaglutide alone
When the same company selling the product is also the one testing it
View Protocol Complete dosage protocol and reconstitution guide for PE-22-28 (10 mg Vial)
Consistently, we found that HZRG modulated the gut dysbiosis, decreased the Firmicutes / Bacteroidetes (F/B) ratio in NASH mice
