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Wang, H.N

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Administration of an acylated GLP-1 and GIP preparation provides added beneficial glucose-lowering and insulinotropic actions over single incretins in mice with type 2 diabetes and obesity

The primary mechanism involves GLP-1 (glucagon-like peptide-1) receptor activation, which slows gastric emptying and increases satiety signals to the brain

Furthermore, in appendiceal ligation and puncture-mediated sepsis, investigators found a decrease in GSH content and GPX4 expression and an accumulation of cardiac iron content and lipid peroxidation levels [94]