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And the clinics selling these things are multiplying faster than the research can keep up with them

Importantly, there is an absence of data demonstrating development of chronic pancreatitis in humans treated with GLP-1RAs to support this connection

Some users may also experience temporary water retention or numbness in the hands and wrists

The safety has not been well studied

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With heterogeneous evidence of the cardiovascular benefit, mortality, and potential risks of intensive glycemic control reported in several recent clinical trials, achieving good blood glucose control without increasing cardiovascular risk factors such as hypoglycemia and body weight gain is becoming more important [3,4,5,6,7]