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Since B12 is a water-soluble vitamin, any excess is naturally eliminated by the body, which makes the treatment well-tolerated for most people

Preclinical studies demonstrated that AOD-9604 was generally safe after chronic oral application in rats and cynomolgus monkeys, with no genotoxic concerns identified

(PubMed) Egnell M, Fassier P, Lecuyer L, et al

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Am J Surg 201 (1): 70-5 (2011) The disposition and urinary excretion pharmacokinetics of methylene blue were determined after its intravenous administration at 15 mg/kg to mature female sheep

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