doi: 10.1038/s41392-024-01738-y 67 JesulolaEMicalosPBaguleyIJ
Start your intake Headaches in GLP-1 Clinical Trials: What the Data Shows In the ZEPBOUND trial (SURMOUNT-4), headache was reported by approximately 25% of participants taking the highest dose of tirzepatide, compared to 16% in the placebo group
FDA-approved for treating obesity, as well as other conditions, including sleep apnea, the medications are increasingly being used off-label by people who dont qualify based on factors like their BMI (which has long been a controversial measure of health, FWIW)
Dogra S, Beydoun S, Mazzola J, Hopwood M, Wan Y
Mechanistically, L2HG acts as a metabolic-epigenetic regulator that inhibits 2-oxoglutarate-dependent dioxygenases, induces histone hypermethylation, and remodels chromatin accessibility to activate an ATF3-dependent transcriptional program
Chronic microbial colonization of the skin (e.g., Staphylococcus aureus, Pityrosporum ovale ) and superinfection are possible additional provocation factors and should be treated (Cooper, 1994)
