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This protocol was applied to exacerbate metabolic impairment in the models of PCOS, commonly seen in this syndrome, and as a means to define adverse conditions where to test the therapeutic potential of the selected multi-agonists

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evaluating metformin, liraglutide, and combination therapy (metformin 1000 mg BID + liraglutide 1.2 mg/day), only the latter treatment resulted in significant decrease in body weight and androstenedione levels [61]