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While previous generations of research compounds focused on one or two hormonal pathways, Retatrutide is engineered to activate three: the glucagon-like peptide-1 (GLP-1) receptor, the glucose-dependent insulinotropic polypeptide (GIP) receptor, and the glucagon receptor (GCGR)

Both are delivered as pens for subcutaneous injection

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Compounded medications are only indicated for patients when a prescribing practitioner determines that the compounded preparation produces a significant difference for their patient compared to the FDA-approved product

The Bottom Line on Kaiser and GLP-1s in 2026 Kaiser Permanente is not the easiest path to a GLP-1 prescription