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Based on the amount of GSH in the lysate, we calculated the GSH concentration assuming an averaged HeLa/HT1080 cell volume of 4,000 m 3 (refs 15, 51, 52)

Remarkably there was a clear separation in what is called ACR50 in just the first 4 weeks of treatment in the patients taking tirzepatide plus Taltz together

Full estimates are demonstrated in Figure 3

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