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For the semaglutide 1-mg-containing groups, semaglutide was initiated at 0.25 mg once weekly for the first 4 weeks, increased to 0.5 mg from weeks 5 to 8 and increased to 1.0 mg from weeks 9 to 71

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So both semaglutide options share similar gastrointestinal side effects, including: Nausea Vomiting Diarrhea Constipation Abdominal pain Decreased appetite Additionally, oral consumption of semaglutide has been linked to higher rates of discontinuation early on

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Anti-inflammatory and immunomodulatory properties of 1-antitrypsin without inhibition of elastase