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If weight is the goal, track that separately from B12 correction and use interventions designed to create lasting fat loss

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Weight loss with Tesofensine was primarily fat mass, with a notable preservation of lean mass as assessed by DEXA. Astrup et al., The Lancet May Improve Training Drive and Mood Elevated dopamine and norepinephrine levels can enhance motivation , focus , and mental resilience during challenging cutting phases

They are beneficial for individuals with B12 deficiency or absorption issues

Tkalcevi VI et al