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Intestinal motility dysfunction is a key contributor to constipation, leading to prolonged retention of intestinal contents and increased water reabsorption, which results in harder, drier stools (20, 21)

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Patients with inflammation of the joint are often excluded from cartilage repair attempts given that catabolic cytokines and proteinases (MMPs) present in the synovial fluid degrade the native ECM, and would similarly degrade any implanted tissue, predisposing treatment failure

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The connection between stress and GLP-1 function runs deeper than most people realize