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Lastly, although female mice are generally more resistant to DIO and glucose intolerance, we observed no sex differences in the percentage of body weight loss in CNS GLP-1R KO mice treated with mGIPR-Ab/P1

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Group I (Control group): Rats were given subcutaneously injections of 0.5% acetic acid in distilled water for a period of 3 days, afterwards saline was intraperitoneally injected for 14 days