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Research suggests that without protective measures, approximately 2030% of weight lost during energy restriction may come from lean body mass, though this varies considerably between individuals

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Thyroid considerations: In animal studies, GLP-1 receptor agonists have been associated with thyroid C-cell tumours, though relevance to humans remains uncertain

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Patients achieving a reduction from baseline of at least 10%, 15%, and 20% were confirmatory secondary outcomes in the STEP 1 to STEP 3 studies, and the differences between semaglutide and placebo were statistically significant at each of these thresholds, across all of the studies (Table 23)