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Repeated aripiprazole treatment regulate Bdnf, Arc and Npas4 expression under basal condition as well as after an acute swim stress in the brain

Based on a previous methodology (Zhang et al., 2020), animals were randomized into six experimental cohorts (n = 8 each): a healthy Control, a DSS-only Model, a positive control group receiving Sulfasalazine (SASP, 200 mg/kg via gavage), and three ATT-I (Macklin, A860603, China) intervention groups administered intraperitoneally at dosages of 10, 20, and 40 mg/kg (saline containing 0.1% DMSO) from day 0 to day 10 once every day

Although certain trials demonstrate benefits in insulin sensitivity and hepatic steatosis, others report neutral outcomes

That means they havent gone through the same testing for safety, effectiveness, or quality