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SGLT2 inhibitors are effective in preventing MACE and hospitalization for heart failure, and GLP-1RAs also have comparable effects on MACE consistently in older patients with diabetes at a high cardiovascular risk

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Tirzepatide activates two receptors (GLP-1 and GIP), delivering greater average weight loss in trials, but your specific genetic variants determine whether that dual mechanism benefits you

But heres what really matters if youre dealing with type 2 diabetes (T2D) The REDEFINE 2 trial showed CagriSema achieving 13.7% weight loss vs 3.4% with placebo at 68 weeks in T2D patients

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Here we address the question in nematodes, where the number of genes encoding PUF proteins has expanded during evolution, yielding functional specialization among family members