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GSH is synthesized in two steps, both ATP-dependent processes, catalyzed by the enzymes GCL (glutamate-cysteine ligase, aka -glutamylcysteine synthetase) and glutathione synthetase, and is regenerated by six enzyme-catalyzed reactions, known as the -glutamyl cycle

14 It also acts as an anti-proliferative agent and indices apoptosis by a) changing the mitochondrial membrane barrier, b) increasing reactive oxygen species, c) decreasing internal glutathione level , 76,77 d) increasing cytochrome-C activity, e) disturbing B-cell lymphoma-2 and B-cell lymphoma-2-associated X protein (Bcl/Bax) proportion, f) increasing caspase 3 and caspase 9 action, and g) poly ADP ribose polymerase

Addressing vaccine inequity Covid-19 vaccines as a global public good

[DOI] [Google Scholar] Dindar B, Icli S

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