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Losing weight triggers all kinds of biological responses that undermine the loss

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Instead of letting fat burn, the brain protects stored energy by: Slowing metabolism Increasing hunger Triggering cravings Lowering energy levels These physiological responses are not signs of failure

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NICE guidance (CKS: Lymphadenopathy and NG12: Suspected cancer) recommends a systematic approach to investigating unexplained lymphadenopathy, with urgent referral (within two weeks) for suspected cancer when specific criteria are met