To understand the mechanism underlying the role of MOTS-c in protecting pancreatic islets from senescence, we performed gene microarray analyses in pancreatic islet cells treated with either MOTS-c or a scrambled peptide
PubMed Harris, C., Coskun, T., Wu, Q., Schloot, N.C., Haupt, A., Milicevic, Z., Khouli, C., & Hartman, M.L
Researchers assessed outcomes for people who were prescribed either a GLP-1 or an SGLT2 medication after their initial stroke to determine if there was a potential impact on the risk of having a second stroke, a heart attack or dying
Semaglutide has an isoelectric point at pH 5.4, meaning the molecule carries no net charge at this pH and is most prone to aggregation
Unlike older GHRPs, it selectively triggers a GH pulse without significantly affecting other hormones like cortisol (the stress hormone) or prolactin
PMID: 25373535